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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using FLT3 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using FLT3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to FLT3

  • 货号:

    30507
  • 别名:

    FLK2; STK1; CD135; FLK-2
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P36888
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to FLT3

Description

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

References

1. J Immunol. 2012 Oct 15;189(8):3822-30.
2. Cancer. 2012 Dec 15;118(24):6110-7.

Specification

Aliases FLK2; STK1; CD135; FLK-2
Entrez GeneID 2322
Swissprot P36888
clone 7B7C3
WB Predicted band size 130kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
ELISA 1/10000
XML 地图