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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using AKT1 mouse mAb against A549 (1), MCF-7 (2), Hela (3), COS7 (4), C6 (5), and HL-60 (6) cell lysate.
Flow cytometric analysis of Hela cells using AKT1 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using AKT1 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using AKT1 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to AKT1

  • 货号:

    30997
  • 别名:

    AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human,Rat,Monkey
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P31749
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to AKT1

Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

References

1.Sci Rep. 2015 Jan 13;5:7758.
2.J Cancer Res Clin Oncol. 2015 Apr;141(4):615-26.

Specification

Aliases AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Entrez GeneID 207
Swissprot P31749
clone 1F7G2
WB Predicted band size 55.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat,Monkey
Immunogen Purified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图