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Rabbit Polyclonal Antibody to NOTCH1
-
货号:
P11286 -
别名:
hN1; AOS5; TAN1; AOVD1 -
应用:
WB,IHC -
反应种属:
Human, Rat -
抗体类型:
Primary antibody -
Swissprot:
P46531 -
规格:
-
数量:
-+ -
说明书:
目录价¥1980

Rabbit Polyclonal Antibody to NOTCH1
Description |
---|
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. |
Specification |
|
---|---|
Aliases | hN1; AOS5; TAN1; AOVD1 |
Swissprot | P46531 |
WB Predicted band size | 272 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Rat |
Immunogen | Synthetic peptide of human NOTCH1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
---|---|
WB | 1/500-1/2000 |
IHC | 1/50-1/100 |
ELISA | 1/5000-1/10000 |
Product Image
- Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela, HepG2, 293T cell lysates, Primary antibody: P11286(NOTCH1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds
- The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P11286(NOTCH1 Antibody) at dilution 1/50. (Original magnification: ×200)
- The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11286(NOTCH1 Antibody) at dilution 1/50. (Original magnification: ×200)
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#P11286

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