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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of Hela cells using SDHB mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using SDHB mouse mAb with DAB staining.

Mouse Monoclonal Antibody to SDHB

  • 货号:

    31841
  • 别名:

    IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P21912
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to SDHB

Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

References

1.Endocrine. 2017 Sep;57(3):512-517.
2.J Natl Cancer Inst. 2016 Jan;108(1).

Specification

Aliases IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Entrez GeneID 6390
Swissprot P21912
clone 2B2B1
WB Predicted band size 31.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图