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Western blot analysis of extracts from JK cells untreated or treated with H2O2 for the indicated times, using syk(phospho-Tyr323) Antibody P40329.

Immunofluorescence staining of methanol-fixed Hela cells using syk(phospho-Tyr323) Antibody P40329.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using syk(Phospho-Tyr323) Antibody P40329(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to syk(phospho-Tyr323)

货号：
P40329
别名：
Spleen tyrosine kinase
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P43405
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to syk(phospho-Tyr323)

Description
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

Description

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

References
Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447.Turner, M. et al. (2000) Immunol. Today 21, 148-154.Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874.Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315.

Specification
Aliases	Spleen tyrosine kinase
Entrez GeneID	6850;
Swissprot	P43405
WB Predicted band size	72kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 323 (N-P-Y(p)-E- P) derived from Human syk.
Formulation	Purified antibody in PBS with 0.05% sodium azide.