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Western blot analysis of extracts from COS7 cells treated with Adriamycin using Abl (Phospho-Tyr204) antibody P40543.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to Abl (Phospho-Tyr204)

货号：
P40543
别名：
p150; c-ABL; EC 2.7.10.2;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P00519
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to Abl (Phospho-Tyr204)

Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).

Description

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).

References
Meyn MA, et al. (2006) J Biol Chem 281, 30907-16 Steen H, et al. (2003) Mol Cell Proteomics 2, 138-45 Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8

Specification
Aliases	p150; c-ABL; EC 2.7.10.2;
Entrez GeneID	25;
Swissprot	P00519
WB Predicted band size	135kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y(p)-V-S) derived from Human c-Abl.
Formulation	Purified antibody in PBS with 0.05% sodium azide.