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Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) antibody P40545.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to Trk A (Phospho-Tyr680/681)

货号：
P40545
别名：
High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth; TRK; Trk-A
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P04629
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to Trk A (Phospho-Tyr680/681)

Description
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Liu HY, et al. (2005) J Biol Chem 280, 19461-71 Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51 Marsh HN, et al. (2003) J Cell Biol 163, 999-1010

Description

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Liu HY, et al. (2005) J Biol Chem 280, 19461-71 Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51 Marsh HN, et al. (2003) J Cell Biol 163, 999-1010

Specification
Aliases	High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth; TRK; Trk-A
Entrez GeneID	4914;
Swissprot	P04629
WB Predicted band size	87kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A.
Formulation	Purified antibody in PBS with 0.05% sodium azide.