Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Choi DW, et al. (2013) Mol Cell 51, 374-85 Bagashev A, et al. (2013) Cell Cycle 12, 1569-77 Shahar OD, et al. (2013) PLoS One 8, e78472