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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using CDK4 mouse mAb against COS-7 (1), and NIH/3T3 (2) cell lysate.
Flow cytometric analysis of Hela cells using CDK4 mouse mAb (green) and negative control (red).
Flow cytometric analysis of HepG2 cells using CDK4 mouse mAb (green) and negative control (red).
Flow cytometric analysis of Raji cells using CDK4 mouse mAb (green) and negative control (red).
Flow cytometric analysis of THP-1 cells using CDK4 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CDK4 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues using CDK4 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to CDK4

  • 货号:

    32132
  • 别名:

    CMM3; PSK-J3
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human, Mouse, Monkey
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P11802
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CDK4

Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

References

1,Cancer Res. 2019 Oct 15;79(20):5245-5259.
2,J Dermatol. 2019 May;46(5):444-448

Specification

Aliases CMM3; PSK-J3
Entrez GeneID 1019
Swissprot P11802
clone 4G9F1
WB Predicted band size 33.7kda
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Monkey
Immunogen Purified recombinant fragment of human CDK4 (AA: 77-303) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图