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Western blot analysis of extracts from HT29, Hela and 293 cells using FAK(Ab-861) Antibody P41303.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK(Ab-861) Antibody P41303(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to FAK(Ab-861)

  • 货号:

    P41303
  • 别名:

    FADK 1; FAK1; PTK2
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q05397
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥1980

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Rabbit Polyclonal Antibody to FAK(Ab-861)

Description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

References

Shi Q, et al. (2003) Mol Biol Cell; 14(10): 4306-15.Vadlamudi RK, et al. (2003) FEBS Lett; 543(1-3): 76-80.Eliceiri BP, et al. (2002) J Cell Biol Apr 01; 157(1): 149-60.Abu-Ghazaleh R, (2001) et al. Biochem J; 360(Pt 1): 255-64.Slack JK, et al.(2001) Oncogene; 20(10): 1152-63.

Specification

Aliases FADK 1; FAK1; PTK2
Entrez GeneID 5747;
Swissprot Q05397
WB Predicted band size 125kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa. 859~863 (H-I-Y-Q-P) derived from Human FAK.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#P41303

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