Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

References
Greenwood J, et al. (2003) J Immunol; 171(4):2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol; 513(1-2):1-8. Chen YH, et al. (2001) J Cell Biochem; 82(3):512-521

Specification
Aliases	ICA1; ICAM1;
Entrez GeneID	3383;
Swissprot	P05362
WB Predicted band size	89-92kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000