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Western blot analysis of extracts from Hela cells using FKHR(Ab-256) Antibody P41354.

Immunofluorescence staining of methanol-fixed Hela cells using FKHR(Ab-256) Antibody P41354.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FKHR(Ab-256) Antibody P41354(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to FKHR(Ab-256)

货号：
P41354
别名：
FOXO1
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q12778
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to FKHR(Ab-256)

Description
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

Description

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

References
Gan L, et al. (2005) J Neurochem; 93(5): 1209-19. Smith WW, et al. (2005) J Cell Biol; 169(2): 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12(6): 668-77. Horn S, et al. (2004) Leukemia; 18(11): 1839-49. Zhao X, et al. (2004) Biochem J 4; 378(Pt 3): 839-49.

Specification
Aliases	FOXO1
Entrez GeneID	2308;
Swissprot	Q12778
WB Predicted band size	78-82 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A.
Formulation	Purified antibody in PBS with 0.05% sodium azide.