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Western blot analysis of extracts from 293 cells using Pyk2(Ab-402) Antibody P41413.

Immunofluorescence staining of methanol-fixed Hela cells using Pyk2(Ab-402) Antibody P41413.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2(Ab-402) Antibody P41413(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to Pyk2(Ab-402)

货号：
P41413
别名：
FADK 2; FAK2; Focal adhesion kinase 2; PTK2B; Proline-rich tyrosine kinase 2 RAFTK
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q14289
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Pyk2(Ab-402)

Description
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Description

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

References
Gluck SL, et al. (2004) J Clin Invest; 114(12): 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22(8): 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21(12): 4016-4031Krishnan HH, et al. (2006) J Virol; 80(3): 1167-1180

Specification
Aliases	FADK 2; FAK2; Focal adhesion kinase 2; PTK2B; Proline-rich tyrosine kinase 2 RAFTK
Entrez GeneID	2185;
Swissprot	Q14289
WB Predicted band size	140kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2.
Formulation	Purified antibody in PBS with 0.05% sodium azide.