Description
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.

References
Hwang, S.G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915.Yamada, S. et al. (2005) Cell 123, 889-901.Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.

Specification
Aliases	Cadherin-associated protein; Alpha E-catenin; NY-REN-13 antigen
Entrez GeneID	1495;
Swissprot	P35221
WB Predicted band size	100kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa. 639~643 (D-D-S-D-F) derived from Human a-catenin.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000