Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

References
Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.Li, P. et al. (1997) Cell 91, 479-489.

Specification
Aliases	ICE-like apoptotic protease 6
Entrez GeneID	842;
Swissprot	P55211
WB Predicted band size	47 37 35kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000