Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.Matthew Bjerknes, Am. J. Pathol., Jun 1999; 154: 1831. T Maltzman, Carcinogenesis, Dec 1997; 18: 2435 - 2439. Jean Schneikert, Hum. Mol. Genet., Jan 2007; 16: 199 - 209. Dhaval M. Patel, J. Immunol., Nov 1999; 163: 5201