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Rabbit Polyclonal Antibody to AurB/C (Ab-202/175)
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货号:
P41681 -
别名:
AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3 -
应用:
WB -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q9UQB9 -
规格:
-
数量:
-+ -
说明书:
目录价¥1980

Rabbit Polyclonal Antibody to AurB/C (Ab-202/175)
Description |
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Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228' |
References |
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Tseng T.-C., DNA Cell Biol. 17:823-833(1998) Bernard M., Genomics 53:406-409(1998) Kimura M., J. Biol. Chem. 274:7334-7340(1999) |
Specification |
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Aliases | AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3 |
Entrez GeneID | 6795; |
Swissprot | Q9UQB9 |
WB Predicted band size | 39kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthesized non-phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 202/175 (C-G-T(p)-L-D). |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/3000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
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