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Western blot analysis of extracts from 293, Hela and HepG2 cells, using AurB/C (Ab-202/175) antibody P41681.

Rabbit Polyclonal Antibody to AurB/C (Ab-202/175)

  • 货号:

    P41681
  • 别名:

    AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q9UQB9
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥1980

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Rabbit Polyclonal Antibody to AurB/C (Ab-202/175)

Description

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'

References

Tseng T.-C., DNA Cell Biol. 17:823-833(1998) Bernard M., Genomics 53:406-409(1998) Kimura M., J. Biol. Chem. 274:7334-7340(1999)

Specification

Aliases AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3
Entrez GeneID 6795;
Swissprot Q9UQB9
WB Predicted band size 39kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized non-phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 202/175 (C-G-T(p)-L-D).
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#P41681

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