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Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1 alpha (Ab-92) antibody P41740.
Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1 alpha (Ab-92) antibody P41740.
Rabbit Polyclonal Antibody to HP1 alpha (Ab-92)
-
货号：
P41740 -
别名：
antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A -
应用：
WB,IHC -
反应种属：
Human -
抗体类型：
Primary antibody -
Swissprot：
P45973 -
规格：
-
数量：
-+ -
说明书：
目录价¥1980
Rabbit Polyclonal Antibody to HP1 alpha (Ab-92)
Description |
|---|
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.Saunders W.S., J. Cell Sci. 104:573-582(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ye Q., J. Biol. Chem. 271:14653-14656(1996). |
Specification |
|
|---|---|
| Aliases | antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A |
| Entrez GeneID | 23468; |
| Swissprot | P45973 |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
Product Image
For Reseach Only
Application Key：WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
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