Description
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates

References
Nagase T., DNA Res. 7:65-73(2000) The MGC Project Team; Genome Res. 14:2121-2127(2004) Bartee E., J. Virol. 78:1109-1120(2004).

Specification
Aliases	E3 ubiquitin-protein ligase MARCH4 ; EC 6.3.2.-; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MARCH-IV
Entrez GeneID	57574;
Swissprot	Q9P2E8
WB Predicted band size	46kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human MARCH4.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
IHC	1/50-1/100