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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using SOCS3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Jurkat cells using SOCS3 mouse mAb (green) and negative control (red).

Flow cytometric analysis of Hela cells using SOCS3 mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using SOCS3 mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human muscle tissues using SOCS3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to SOCS3

货号：
32296
别名：
CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
产品上架时间：
2024-01-01
应用：
IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O14543
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to SOCS3

Description
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Description

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

References
1，Genet Test Mol Biomarkers. 2020 Jul;24(7):443-450. 2，Eur J Gastroenterol Hepatol. 2020 Apr;32(4):540-541.

Specification
Aliases	CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Entrez GeneID	9021
Swissprot	O14543
clone	5E12E7F1
WB Predicted band size	24.8KDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human SOCS3 (AA: 1-225) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide