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Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal lung tissue Amount of lysate: 30ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds

Rabbit Polyclonal Antibody to DUSP1

  • 货号:

    P42849
  • 别名:

    HVH1; MKP1; CL100; MKP-1; PTPN10
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB
  • 反应种属:

    Human,Mouse
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P28562
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥1980

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Rabbit Polyclonal Antibody to DUSP1

Description

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Specification

Aliases HVH1; MKP1; CL100; MKP-1; PTPN10
Entrez GeneID 1843;
Swissprot P28562
WB Predicted band size 39kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Synthetic peptide corresponding to residues near the C terminal of human dual specificity phosphatase 1
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/2000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#P42849

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