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Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human placenta tissue Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 minutes

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using P43418 at dilution 1/20.

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using P43418 at dilution 1/20.

Rabbit Polyclonal Antibody to FZR1

货号：
P43418
别名：
FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9UM11
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to FZR1

Description
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.

Description

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.

Specification
Aliases	FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
Entrez GeneID	51343;
Swissprot	Q9UM11
WB Predicted band size	55kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human FZR1
Formulation	Purified antibody in PBS with 0.05% sodium azide.