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Mouse Monoclonal Antibody to ATM
-
货号:
32438 -
别名:
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1 -
应用:
IHC,IF,FCM -
反应种属:
Human, Mouse, Monkey, Rat -
抗体类型:
Primary antibody -
Swissprot:
Q13315 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to ATM
Description |
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The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
References |
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MC Cancer. 2021 Jan 5;21(1):27. Fam Cancer. 2022 Apr;21(2):211-227. |
Specification |
|
---|---|
Aliases | AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1 |
Entrez GeneID | 472 |
Swissprot | Q13315 |
clone | 3H12H8 |
WB Predicted band size | 350.7kDa |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Monkey, Rat |
Immunogen | Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
---|---|
IHC | 1/200 - 1/1000 |
IF | 1/200 - 1/1000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
- Immunofluorescence analysis of Hela cells using ATM mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
- Immunofluorescence analysis of NIH/3T3 cells using ATM mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
- Flow cytometric analysis of Hela cells using ATM mouse mAb (green) and negative control (red).
- Flow cytometric analysis of COS-7 cells using ATM mouse mAb (green) and negative control (red).
- Immunohistochemical analysis of paraffin-embedded human kidney tissues using ATM mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded human gastric cancer tissues using ATM mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded Mouse spleen tissues using ATM mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded Rat myocardium tissues using ATM mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded Rabbit spleen tissues using ATM mouse mAb with DAB staining.
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#32438

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