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Western blot analysis of extract from P19, Hela and 293 cells using AML1(RUNX1) Antibody P41535
Rabbit Polyclonal Antibody to AML1(RUNX1)
-
货号：
P41535 -
别名：
CBFA2; EVI-1; AMLCR1 -
应用：
WB -
反应种属：
Human -
抗体类型：
Primary antibody -
Swissprot：
Q01196 -
规格：
-
数量：
-+ -
说明书：
目录价¥1980
Rabbit Polyclonal Antibody to AML1(RUNX1)
Description |
|---|
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The a subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation. |
References |
|---|
| Mao S., Frank R.C., Zhang J., Miyazaki Y., Nimer S.D.Mol. Cell. Biol. 19:3635-3644(1999) Pelletier N., Champagne N., Stifani S., Yang X.-J. Oncogene 21:2729-2740(2002) Cho J.-Y., Akbarali Y., Zerbini L.F., Gu X., Boltax J., Wang Y., Oettgen P., Zhang D.-E., Libermann T.A.J. Biol. Chem. 279:19512-19522(2004) |
Specification |
|
|---|---|
| Aliases | CBFA2; EVI-1; AMLCR1 |
| Entrez GeneID | 861; |
| Swissprot | Q01196 |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.6~10(D-A-S-T-S) derived from Human AML1(RUNX1). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
Product Image
For Reseach Only
Application Key：WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
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