Description
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

References
1. Mol Cell Biol. 2009 Jun;29(11):3076-87. 2. Cell. 2009 Jul 23;138(2):389-403.

Specification
Aliases	CRKL
Entrez GeneID	1399
Swissprot	P46109
clone	5E12
WB Predicted band size	39kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CRKL expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
FCM	1/200 - 1/400
ELISA	1/10000