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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Western blot analysis using CASP8 mouse mAb against Hela (1), Jurkat (2), THP-1 (3), NIH/3T3 (4), Cos7 (5) and PC-12 (6) cell lysate.
Flow cytometric analysis of NIH/3T3 cells using CASP8 mouse mAb (blue) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using CASP8 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using CASP8 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to CASP8

  • 货号:

    30279
  • 别名:

    CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human,Mouse,Monkey,Rat
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q14790
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CASP8

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

References

1. Cancer Lett. 2009 Aug 28;281(2):128-33.
2. Cell Res. 2009 Mar;19(3):358-69.

Specification

Aliases CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473
Entrez GeneID 841
Swissprot Q14790
clone 1H11
WB Predicted band size 26kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Monkey,Rat
Immunogen Purified recombinant fragment of human CASP8 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图