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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Mouse Monoclonal Antibody to ROCK1

  • 货号:

    30304
  • 别名:

    ROCK-I; PRO0435; MGC43611; P160ROCK; MGC131603
  • 产品上架时间:

    2024-01-01
  • 应用:

  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q13464
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to ROCK1

Description

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. 

References

1. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H893-9.
2. Cancer Metastasis Rev. 2009 Jun;28(1-2):65-76. 

Specification

Aliases ROCK-I; PRO0435; MGC43611; P160ROCK; MGC131603
Entrez GeneID 6093
Swissprot Q13464
clone 1H4
WB Predicted band size 158kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human ROCK1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30304

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