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Mouse Monoclonal Antibody to ROCK1
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货号:
30304 -
别名:
ROCK-I; PRO0435; MGC43611; P160ROCK; MGC131603 -
应用:
-
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q13464 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to ROCK1
Description |
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This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. |
References |
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1. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H893-9. 2. Cancer Metastasis Rev. 2009 Jun;28(1-2):65-76. |
Specification |
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Aliases | ROCK-I; PRO0435; MGC43611; P160ROCK; MGC131603 |
Entrez GeneID | 6093 |
Swissprot | Q13464 |
clone | 1H4 |
WB Predicted band size | 158kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human ROCK1 expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30304

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