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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western blot analysis using NEFL mouse mAb against Hela (1) and Jurkat (2) cell lysate.

Immunofluorescence analysis of Hela cells using NEFL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of Jurkat cells using NEFL mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using NEFL mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using NEFL mouse mAb with DAB staining.

Mouse Monoclonal Antibody to NEFL

货号：
30310
别名：
NFL; NF-L; NF68; CMT1F; CMT2E
产品上架时间：
2024-01-01
应用：
WB,IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P07196
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to NEFL

Description
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Description

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

References
1. BMB Rep. 2008 Dec 31;41(12):868-74. 2. J Hum Genet. 2009 Feb;54(2):94-7.

Specification
Aliases	NFL; NF-L; NF68; CMT1F; CMT2E
Entrez GeneID	4747
Swissprot	P07196
clone	1H3
WB Predicted band size	62kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human NEFL expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.