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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using MRE11 mouse mAb against Hela (1), A431 (2), MCF-7 (3), Jurkat (4), HepG2 (5), K562 (6), COS-7 (7), PC-12 (8) and NIH/3T3 (9) cell lysate.
Flow cytometric analysis of Hela cells using MRE11 mouse mAb (green) and negative control (red).
Flow cytometric analysis of K562 cells using MRE11 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using MRE11 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using MRE11 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded Mouse testis tissues using MRE11 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded Rat testis tissues using MRE11 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded Rabbit testis tissues using MRE11 mouse mAb with DAB staining.
HOT

Mouse Monoclonal Antibody to MRE11

  • 货号:

    32433
  • 别名:

    ATLD; HNGS1; MRE11A; MRE11B
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human, Mouse, Monkey, Rat
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P49959
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to MRE11

Description

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

References

Cancer Lett. 2021 Aug 28;514:1-11.
Diagn Pathol. 2019 Jun 21;14(1):60.

Specification

Aliases ATLD; HNGS1; MRE11A; MRE11B
Entrez GeneID 4361
Swissprot P49959
clone 7C8A9
WB Predicted band size 80.6kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Monkey, Rat
Immunogen Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图