永利集团-www.304am.com|官方网站-Application program

请登录
搜索 英文站
栏目

提醒成功

请输入手机号/邮箱号
请输入密码

账号密码登录

微信/QQ登录 微信/QQ登录

没有账号? 立即注册

搜索
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western blot analysis using RAF1 mouse mAb against Hela (1), A431 (2), Cos7 (3) and C6 (4) cell lysate.
Flow cytometric analysis of Hela cells using RAF1 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using RAF1 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to RAF1

  • 货号:

    30325
  • 别名:

    NS5; CRAF; Raf-1; c-Raf
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P04049
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

加入购物车

Mouse Monoclonal Antibody to RAF1

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

References

1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Mol Cancer Res. 2009 Oct;7(10):1635-44.

Specification

Aliases NS5; CRAF; Raf-1; c-Raf
Entrez GeneID 5894
Swissprot P04049
clone 4G4
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human RAF1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
XML 地图